The aptly named No Matter What Flatbed Rolling Carry-On Duffel Bag from Eagle Creek is rugged and packed with functionality. The Bi-Tech outer material is both abrasion- and water-resistant, and the stress points are reinforced with bartacks to ensure you don't spill your belongings all over the tarmac. This sturdy rolling suitcase features oversized wheels with protective wheel housing and lockable zippers on the outer main compartment for security. An external top pocket lets you keep a few things handy for easy access, and an interior mesh pocket on the inside of the door helps with organization. External compression straps with attached daisy chains make sure that your things are held securely and let you clip a few items to the outside so you can easily grab your water bottle.